Well, I know that a lot of people on here will cringe at the idea, but I paint in my garage all the time. When I paint an overall, I usually hang that clear plastic sheeting and cover the ceiling and walls. I then scrub the floor and squegee it dry. I have a filtered end to draw thru (I wet the concrete down outside to catch dust) and use several fans to draw the vapors through.
The problem is that most of the new clears are catalyzed with some really nasty stuff, unless use use ISO free, which is too much $$$ for me. I actually went and bought a fresh air system that I use any time I spray catalyzed paints.
I have really good results doing it this way, and have very few dust problems.
The other thing to worry about is neighbors. That crap will drift a long way and stick to anything, as well as stink up the neighborhood.......